Why is it so hard to keep the weight off?

A woman chopping vegetables on a cutting board in a kitchen.

When it comes to weight loss, the famous theory is the ‘fat set point’ that is pre-programed in our brain. After we lose certain amount of weight, let us say 15% weight loss; our brain can receive this as threatening signal. Therefore, the brain can release various hormones to help regained the lost weight. Food would look better, and when we actually having the food, it actually tastes better ( though could be the same food we had in the past). We would also have more hunger ( you feel less full at the start of the meal), and delayed satiation ( you need to eat more to feel full).

These are the reasons why weight management requires a multidiscipline approach. We need to work on both the brain and gut. Medication, such as semaglutide, tirzepatide, is perfect example to tackle both brain and the gut system. People have prolonged fullness and less hunger.


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